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Among the distinct cytosolic sensors able to form inflammasomes, the molecule NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) has been implicated in COVID-19 (1720)

It leverages endogenous pathways that deliver essential macromolecules such as transferrin and insulin into the brain

If its production is inhibited or limited, as it is with several types of genetic glitches then dysfunction and disease result

PJ014360), Rural Development Administration, Republic of Korea

There is compelling evidence from preclinical studies that L-carnitine and ALCAR can improve energy status, decrease oxidative stress and prevent subsequent cell death in models of adult, neonatal and pediatric brain injury

PD146176, a 15-LOXselective antagonist, additionally halts the ferroptosis cascade (Ou et al., 2016