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This is a valid concern with GLP-1 **weight loss peptides** approximately 25-40% of weight lost with semaglutide comes from lean mass

Nobody can give you an honest probability of harm because the studies that would generate one have not been done
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In addition to fatigue, a deficiency of B12 can lead to other symptoms like pale skin, headaches, depression, gastrointestinal problems, difficulty concentrating, decreased mental function, mouth and tongue pain or inflammation, and paresthesia in your hands and feet

the elderly, strict vegetarians (i.e., vegan), and patients with malabsorption problems are more likely to become deficient

Kukat et al., 2015)
