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Specialists can provide personalised advice and may consider specific interventions, including vitamin E in carefully selected adults without diabetes who have biopsy-proven NASH, as part of a comprehensive management plan

Lists of genes associated with cancers Lists of genes associated with melanoma (73, hsa05218), gastric cancer (150, hsa05226) and thyroid cancer (37, hsa05216) were retrieved from KEGG

This is particularly relevant for combination strategies involving immunotherapy and metabolic pathway targeting, offering new avenues to overcome therapeutic resistance

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doi: 10.1042/BJ20070891

Furthermore, in vitro studies demonstrated that melatonin can enhance the effect of 5-fluorouracil in colon cancer cells via the activation of caspase-9 and caspase-3 in the mitochondrial apoptotic pathway [160], increasing oxidative stress, downregulating genes and proteins related to apoptosis resistance [161], and inhibiting NF-B/iNOS and PI3K/AKT signaling pathways [162]