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A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

HMDB: a knowledgebase for the human metabolome

More precisely, the complex bearing the most lipophilic benzoate ligand, 3P , showed the highest in vitro antiproliferative activity (mean IC 50 equal to 2.6 M), whereas the complexes with a more hydrophilic carboxylate, such as succinate and acetate, 4P and 5P , were endowed with a lower cytotoxic activity (mean IC 50 of 30.4 and 11.1 M, respectively)

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Food Science & Nutrition, 7(8), 25842594

During periods of high metabolic demand, intense physical exertion, or cellular stress, the mitochondria can become overwhelmed by partially processed metabolic byproducts, specifically excess acetyl-CoA