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The honest summary: this isn't a compound with five large randomized controlled trials behind it

Treatment with FOXO4-DRI at 25 M in serum-limited senescent fibroblast and keloid organ culture models promoted apoptosis, decreased G0/G1 phase cells, and induced p53-pS15 nuclear exclusion confirmed by Annexin V-FITC/PI apoptosis assays and TUNEL staining of keloid organ cultures at days 3, 7, and 10

REDEFINE 1 (Phase 3a, NEJM 2025) Garvey et al., n=3,417, 68 weeks

Follow-up sessions are typically scheduled every 4 to 6 weeks during the initial series

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 10% by weight of the poloxamer

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