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If ever disrupted, mucous membranes and tissues turn susceptible to invasive microbes and the process of inflammation

AGEs not only react with biomolecules such as proteins and lipids but also exacerbate oxidative stress, impairing the energy metabolism of cardiomyocytes and ultimately leading to cardiac dysfunction (84)

Furthermore, mitochondrial-related genes, including COX1, Nrf1, TFAM, and SIRT1, are downregulated in ischemic cardiomyopathy-induced HF 118

This action involves the oxidation and reduction of dangerous compounds

Science 304, 11581160

Viral protein, nsp14 , interacts with the catalytic domain of Sirt1, dysregulates Nrf2/HO1 axis, and impairs host antioxidant defense 53