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Access this article Similar content being viewed by others References Forman HJ, Zhang H, Rinna A (2009) Glutathione: overview of its protective roles, measurement, and biosynthesis
OLT1177 (dapansutrile) is an orally active -sulfonyl nitrile compound that prevents the interaction between NLRP3 and ASC, as well as between NLRP3 and caspase-1, by reducing the ATPase activity of NLRP3 [163]
ATH434 (formerly PBT434), which recently completed a Phase 2 clinical trial for multiple system atrophy (MSA), acts as an orally available iron chaperone that redistributes labile iron in preclinical models of MSA and PD (Bailey et al., 2021
No completed human efficacy trials of the fragment
doi: 10.1038/cdd.2015.158 24 KangHHanMXueJBaekYChangJHuSet al
doi: 10.1007/s10059-012-2188-2
