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When approximately 60 to 80% of the dopamine-producing cells are damaged and do not produce enough dopamine, the motor symptoms of Parkinsons disease appear [68]

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The transcription factor cJun has been shown to regulate glial phagocytosis of axonal debris through activation of the draper protein in Drosophila melanogaster (MacDonald et al., 2013), autophagy and cell death through the regulation of pro and antiapoptotic proteins Bcl2 associated Xprotein (Bax), Bcell lymphoma 2 (Bcl2) (Bogoyevitch et al., 2010)

Seminal publications predating the search window were included if they provided foundational mechanistic, pharmacological, or historical context that was not superseded by subsequent work

Riboflavin and magnesium together have been shown to reduce both migraine frequency and intensity

Melissa Terpstra