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39 Consistent with a role for ABCA1 in alleviating macrophage cholesterol burden in plaques, deletion of bone marrow ABCA1 accelerates atherosclerosis in mice, and humans heterozygous for loss of cholesterol efflux function in the ABCA1 gene are at increased CVD risk

The clearest diagnostic signal is a predictable pattern

Mechanistically, autophagy promotes ferroptosis via a form of cargo-specific autophagy known as ferrotinophagy

Oehr L, Anderson J

Hence, modulation of lipid peroxidation at the host-pathogen interface is an attractive and exciting new area that it needs to further elucidate the specific role of lipid peroxidation in various pathogen infection