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Lung epithelial cells with higher IRP2 expressions are accompanied by increased secretion of airway mucus, elevated airway remodeling, dysregulated infiltrated immune cells expressing inflammatory mediators (IL-33, IL-6), which contribute to the severity of acute COPD exacerbations secretion, and declined FEV1 in CS-induced COPD mice [86, 89, 90]

23,723,724 The crosstalk between these epigenetic markers is of particular importance, since it may lead to the activation of oncogenes or the suppression of tumor suppressor genes, which in turn modulates cancer cell behavior and response to therapeutic interventions

However, further knowledge of the immune response in the spinal cord is needed, and many translational efforts are required in this field

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Auerbach, A

Alterations of gut microbiota by overnutrition impact gluconeogenic gene expression and insulin signaling