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What they did: Isolated human chondrocytes (from osteoarthritis patients and healthy donors) were exposed to AOD-9604 at doses 1 to 1000 nM

10.1097/jto.0b013e3181fb5c22 60 HollingsworthR
(2009) Diabetes Study in diet-induced obese rats examining AOD 9604 effects on serum leptin levels and hypothalamic leptin receptor signaling
Each works through a different mechanism, and the evidence levels are very different

Hormonal interactions are not a documented concern at research doses
