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Advanced / Aggressive Protocol (1 mL = ~10.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)

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However, because this was a retrospective observational study, the findings cannot establish that higher semaglutide doses directly caused the improved cardiovascular outcomes, and unmeasured confounding factors may have influenced the observed associations

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