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In order to increase and enhance the result, it is best to apply a moisturizer directly on top of it We keep the product in the refrigerator after opening and keep it in the same cartridge pull and cover it tightly and the best we keep it in a special outer bottle that is clean and has a dark color and if the box is light transparent we wrap it from the outside with adhesive tape so that the light does not run out Note: product is for external use only