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These reactions can manifest as: While some such injection site reactions may be mild and short-lived, others are more severe and require medical attention

high pharmacologic doses (1-3 g/day) can cause hypotension, insulin resistance, and hepatotoxicity

doi:10.3389/fphar.2021.627533

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Talbert ME, Langefeld CD, Ziegler J, et al

Optic Nerve Atrophy: Use with caution in patients with Leber's diseasea type of hereditary optic nerve atrophyas it may worsen the condition
