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In addition, the growth and hypoxic environment of tumor blood vessels in DLBCL can reduce the permeability and concentration of antitumor drugs in the TME (208), blocking the access of vitamin C to the tumor site
Secondary causes involve brain swelling or damage to central pathways in the brainstem or cerebellum
Micafungin and caspofungin have shown similar clinical safety and efficacy (335)
However, this drug has been found to exert neurotoxic effects

By upregulating GH production, sermorelin also leads to an increase in IGF-1 levels

Incidence of macrolide resistance in Streptococcus pneumoniae after introduction of the pneumococcal conjugate vaccine: population-based assessment