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Natural skin brightening options often include ingredients like turmeric, papaya, or kojic acid from rice fermentation

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, 2019 ,doi: 10.1007/s10157-019-01727-4

It significantly downregulated pro-apoptotic proteins Bax and caspase-3, while upregulating the anti-apoptotic protein Bcl-2, thereby reducing mitochondrial Cyt C release

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Mashimo, T
