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Lotiglipron was discontinued in 2023 owing to unfavourable pharmacokinetic drug-drug interaction data from two Phase I studies and to elevated transaminases indicative of liver dysfunction in a subset of patients 24

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BPC-157 also attenuates serotonin syndrome (DOI-induced head twitch 3844%) and serotonin depletion (PCPA-induced hypolocomotion +2228% locomotor restoration)

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