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The intestinal barrier is a living interface composed of: A single layer of epithelial cells Tight junction proteins regulating passage between cells A protective mucus layer A diverse microbial ecosystem supporting mucosal integrity When functioning correctly, this system allows nutrients to be absorbed while preventing bacteria, toxins, and inflammatory molecules from entering circulation

Once inside the cell, the complex interacts with intracellular copper-responsive pathways which is what enables the downstream gene-modulation effects to translate from topical application into measurable dermal changes

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Results Semax-induced increase and decrease in gene expression The genome-wide expression changes induced by Semax in rat brain cortex tissues damaged by focal ischemia were studied using the genome-wide RatRef-12 Expression BeadChip (Illumina, USA), which contains 22,226 genes, according to NCBI

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