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Journal of Biomechanics, 49 , 19261932

Peer review Peer review information Communications Materials thanks the anonymous reviewers for their contribution to the peer review of this work

doi: 10.1038/s41401-022-00947-x

30 The altered NP cell phenotype can maintain the catabolic environment during disc degeneration 31 and has shown to be responsible for the drop in local pH mediated by, among others, acidsensing ion channels (ASICs) 32 that in turn causes IVD cell loss and ECM breakdown

Together, this combination is highly sought after in research models involving injury recovery, soft tissue repair, and anti-inflammatory studies

(2) corneal nerve fiber density (CNFD)