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reported that NAC enhanced the efficacy of phage-antibiotic therapy against Pseudomonas aeruginosa and Klebsiella pneumoniae , highlighting its role in disrupting biofilms and restoring antibiotic susceptibility (Sui et al., 2025)

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So if you absolutely have to use it because a patients INR is 11 (even if theyre not clinically bleeding) or a patients INR is 4 and theyre having nosebleeds, use as small of a dose as possible to get the patient back in a safe range and mitigate the bleeding