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Use standard laboratory personal protective equipment (PPE) and dispose of materials according to institutional waste procedures

The mechanism of action is attributed to the GIP/GLP-1 receptor co-agonism being enhanced by glucagon receptor activation and augmentation of energy intake, substrate utilisation and energy expenditure [60]

Human dosing protocols in the community commonly use 250 mcg to 500 mcg daily, but these are extrapolations from animal data, not validated human trial doses

Randomization Process for assigning participants to different treatment groups within a clinical trial

Expecting rapid changes from short-term use may not align with how the peptide works

Protagonist and Takeda present longer-term data at ASH 2025 showing rusfertide delivers durable response and hematocrit control in polycythemia vera