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Wu W, Hai Y, Chen L, Liu RJ, Han YX, Li WH, Li S, Lin S, Wu XR., "Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity", Pharmacology research & perspectives 4 (2:e00212): 1-15 (2016)

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There were several limitations of our work, the main one being that this was an in vitro study using human cell lines in 2D cell cultures

Furthermore, the early symptoms of type 2 diabetes and hypertension are also dysfunctions caused by the reduced biological availability of NO in endothelial cells [60,61]