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Critical evaluation of latanoprostene bunod in the treatment of glaucoma

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There is spongiosa in the interradicular bone in the furcation area

Simultaneously, the mechanical properties of the ECM change significantly: the shear stiffness of the human nucleus pulposus increases from 12.5 kPa in Pfirrmann grade 116.5 kPa in grade V (Walter et al., 2017), collagen fibers thicken and become disorganized (Leung et al., 2014), its aggrecan synthesis decreases while degradation increases (Wuertz et al., 2007) (Table 1)

2016;167(5):1339-1353.e21

Chondroitin sulphate is known for its ability to maintain tissue integrity and provide structural support [29,30]