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8 , e2897 (2017)

These findings suggest that optimal NAMPT levels and activity are critical for healthy aging and overall organismal homeostasis, and both upregulation and targeted inhibition may offer potential interventions depending on the specific context and tissue

A., Sriprasert, I., Kono, N., Cai, Z., Karim, R., DeYoung, J., Mack, W

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Moreover, ferroptotic stress may not only contribute to tissue damage but also release proinflammatory mediators and damage-associated molecular patterns (DAMPs), reinforcing inflammation and accelerating tissue degeneration