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In the SURMOUNT-1 trial, 24-26% of participants experienced nausea at some point during the study, most commonly during dose escalation phases
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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Rudolphi B, Zapp B, Kraus NA, Ehebauer F, Kraus B, Kraus D

We always recommend completing your full treatment regimen for the best results

Sleep and circadian restoration Researchers specifically targeting sleep improvement might emphasize bedtime administration and potentially start with lower doses to assess individual sensitivity to melatonin-related effects
