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Singlet oxygen ( 1 O 2 ) Thermo #S36002 (in lysates fluorometry)

Topoisomerase inhibitors: Camptotheca (Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan), Podophyllum (Etoposide, Teniposide)

Excessive ROS production or depletion of antioxidant capacity leading to heightened oxidative stress has been implicated in fibrotic development across multiple organs, including the heart, liver, and lungs [46]

This cautious approach is essential to ensure the success of the therapeutic process and optimize clinical outcomes

The authors also did not find any increase of degeneration of intervertebral discs adjacent to the fractures compared to the controls in this young cohort