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A shift towards a more oxidizing environment (lower GSH/GSSG ratio) can trigger specific post-translational modifications on proteins, most notably S-glutathionylation

Glutathione is a major antioxidant as the cofactor for glutathione peroxidase, one of the most important antioxidant enzymes in the body

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This allows for the removal of the cells affected by oxidative damage, leads to the preservation of tissue integrity, and prevents the convergence of white blood cells