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84 A phase I trial assigned approximately 50 participants with a BMI between 30 and 40 kg/m 2 without diabetes to single ascending dose (SAD), multiple ascending doses (MAD) or placebo

Depending on the nerves affected, peripheral neuropathy may also lead to: Loss of sensation in the hands or fingers Sharp pains Weakness or loss of fine motor skills 5

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DSIP: the delta-wave sleep promoter Delta sleep-inducing peptide is a nonapeptide (nine amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from the hemodialysates of sleeping rabbits in 1977

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