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Furthermore, butyrate inhibits histone deacetylase activity, protecting pancreatic cells and reducing liver fibrosis [118, 119]

Enhanced ROS production is associated with intestinal inflammation and increased levels of (pro-inflammatory) cytokines such as TNF-, IL-6, and IL-1 through the activation of NF-B (Wang et al., 2008

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This accumulation contributes to the generation of oxidative free radicals and peroxides, which subsequently lead to impaired protein function and ultimately result in ferroptosis (Cobley et al., 2018)

The third row shows the transport velocities of GSH and GSSG from the cell into the blood