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Genetic as well as pharmacological inhibition of Epha4 signaling was able to rescue the mutant SOD1 phenotype in zebra fish and increased survival in mouse and rat models of ALS by promoting neuromuscular re-innervation in late stages of ALS[39]

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GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

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The review by Bhushani and Anandharamakrishnan (75) also confirmed that electrospinning and electrospraying are non-thermal processes capable of generating nano- or microscale fiber and particle systems without compromising heat-sensitive compounds such as proteins and antioxidants

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