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doi: 10.3390/vaccines11020470 127 JangW

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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Chang L., Geng B., Yu F., Zhao J., Jiang H., Du J., Tang C

Therapeutic strategies targeting the response to oxidant injury have also been investigated

GPx enzymes use glutathione to neutralize hydrogen peroxide and lipid hydroperoxides the primary sources of oxidative damage to cellular membranes, proteins, and DNA.* Phase II liver detoxification: Glutathione is the substrate for glutathione S-transferase (GST) enzymes the primary phase II conjugation enzymes responsible for conjugating glutathione to electrophilic compounds including environmental toxins, pharmaceutical metabolites, and hormone metabolites such as estrogen metabolites