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doi: 10.1038/ncomms14712

Pyrogallol protects against influenza A virus-triggered lethal lung injury by activating the Nrf2-PPAR--HO-1 signaling axis

Lipid peroxidation during ferroptosis proceeds as follows: (1) the initial reaction occurs between ROS (e.g., hydroxyl radicals), that seem to be derived from NADPH oxidase rather than mitochondrial ETC, at least under some circumstances (Dixon et al., 2012), and hydrogen atoms in unsaturated lipids, typically polyunsaturated fatty acids (PUFAs)

This multi-target action is NAD+'s greatest advantage

Cancer 11 (11), 775791
2009 Aug;43(8):697-705
