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Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet

Gabriele et al

pastoris strains with alanine scanning versions of the putative transporter and analysis with in vivo fluorescent redox biosensors (6 months in the 1st year), generation of tagged versions for proteomics and microscopy as well as generation of knockout or overexpression mutants of interaction partners and all cultivations (4-6 months each in years 2 and 3) will be performed in the group of Brigitte GASSER

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Upon binding to its receptor (TNFR), TNF- initiates a distinct signaling cascade that also converges on the activation of the IKK complex, leading to the liberation of the canonical NF-B heterodimer, p50/p65 (RelA)