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Considering the critical role of mitochondria, we outline mitochondrial dysfunction in oxidation and antioxidation, mitochondrial dynamics, mtDNA damage, and mitophagy

Nakayama et al., 2023

Loss of system x c does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility

Another deleterious pathology associated with mTOR activation is insulin resistance which can lead to suppressed glucose metabolism and insufficient ATP production (Di Domenico et al

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