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Oxidation of methionine and acetyl of the n-terminus were specified in Sequest-HT as variable modifications

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The role of disulfide bounds in the stability of focal adhesion proteins are largely depicted in the control of cell surface receptors [19] as well as the role of extracellular protein disulfide isomerases in the regulation of integrins, in platelet adhesion and thrombosis [10] and more recently in cancer cell migration and invasiveness [8, 20]

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