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doi:10.1038/s41392-025-02253-4

Reticulocytes are active in protein synthesis

It does not mean the treatment is wrong necessarily but may mean you need to lower your dosage significantly and slow down the process to a rate you can tolerate

10.1016/0006-291x(89)92672-7 186 SchapiraA
it depletes GSH indirectly through oxidation, and enzyme activity may decline secondarily (~35% in some studies), but this is not the primary cause. Option (D): Primaquine decreases reduced glutathione levels by promoting its oxidation to combat ROS, not increases them. Introduction: Unraveling Primaquine Hemolytic Anemia and NADPH Demand Primaquine hemolytic anemia strikes G6PD-deficient patients when the drugs metabolites spike NADPH demand for antioxidant protection
[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Mudaliar S., Henry R.R., Sanyal A.J., Morrow L., Marschall H., Kipnes M., Adorini L., Sciacca C.I., Clopton P., Castelloe E., et al
