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Finally, Kim et al

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2) The study performed by Li et al employed a multi-pronged experimental design, integrating human tissue analysis, in vitro cell culture, and in vivo animal models to comprehensively investigate the role of FOXO4 in age-related male fertility and the therapeutic potential of FOXO4-DRI

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TMAO (trimethylamine-N-oxide) has been linked to cancer through mechanisms that activate pro-inflammatory pathways (e.g., NF-B, MAPK), increase oxidative stress by enhancing reactive oxygen species (ROS), and dysregulate cellular metabolism, particularly lipid and cholesterol processing