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10.1016/j.bbalip.2017.03.011

Therefore, the development of novel and versatile methodologies for modifying AONs with precise control over these critical features remains a significant endeavour 23

FIGURE 1 4.1 Autonomic nerve remodeling 4.1.1 Autonomic balance regulation Cardiac autonomic regulationsympathetic and parasympathetic balancecritically governs myocardial function, with its dysfunction being a primary driver of cardiac injury and heart failure (Floras, 2009)

30 , 31 Several preclinical studies have investigated the effect of high doses of vitamin C on challenging tumours such as glioblastoma multiform (GBM), breast cancer, colorectal cancer, mesothelioma and pancreatic cancer and showed promising results on the anticancer effect of vitamin C through hampering the tumour progression and tumour metastasis