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The rats were kept in separate cages at a controlled temperature (21 2) under a 12-h light-dark cycle with ad libitum access to food and water

However, it is unlikely that full replacement of animal studies will occur in the near future, particularly for systemic toxicity and immunogenicity assessments

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& Betschart, C

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Issues Ment Health Nurs 21(7):711720 Maji T, Pluta JP, Mell T, Treusch Y, Gutzmann H, Rapp MA (2012) Correlates of agitation and depression in nursing home residents with dementia