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Dai Y, Wang H, Lian A, Li J, Zhao G, Hu S, Li B

Ligand-based protein alignment and isozyme specificity of glutathione S-transferase inhibitors

Data are representative of minimum three independent experiments and the number of biological replicates is quoted in the figure legends

Decreased expression of GPx1, due to the cellular accumulation of S-adenosylhomocysteine, was found to promote oxidative stress, as hydrogen peroxide release from cells (measured by Amplex Red) as well as intracellular hydrogen peroxide production (measured by Hyper, a live-cell hydrogen peroxide probe) were enhanced by exposure of endothelial cells to increased amounts of S-adenosylhomocysteine

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