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As it is known that transactivation of Met can occur via epidermal growth factor (EGF)-dependent EGF receptor (EGFR) activation or through a constitutively activated EGFR pathway 20 , we examined whether inhibition of EGF-induced phosphorylation of EGFR by the dimeric macrocycles caused the bell-shaped response mentioned above

10.1371/journal.pone.0144854 122 UlluwishewaD.AndersonR

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