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11 , 12 , 13 , 14 Isatuximab is approved for the treatment of adult patients with RRMM in combination with pomalidomide and dexamethasone (Pd), and in combination with carfilzomib and dexamethasone (Kd), in patients who have received at least two prior therapies, including lenalidomide and a PI, or who have received onethree prior lines of therapy, respectively

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This simplified the trial design but raises legitimate questions about whether weight-based dosing might improve outcomes

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