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Age matched Cpt1b m/ mice and control Cpt1b fl/fl mice were fed a breeders chow diet consisting of 25% calories from fat (Purina Rodent Chow no

Nat Rev Drug Discov 9:373386

That controlling point is also recognized in the most recent reviews (Sikiric et al., 2018)

For example, while the absence of functional GHR was reported to cause an increase in systemic GH levels, a decrease in circulating IGF-1 level (but still present), and a delay in puberty onset with a reduced number of ovarian follicles, these animals could still reproduce, but with a smaller litter size (2124)

Local injections or topical delivery to reproductive tissues lessen systemic exposure, but long-term human safety data still do not compare with decades of use in NSAIDs and steroids