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[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Arner ES, Holmgren A

The cytoprotective action of BPC-157 may indicate that it becomes its new mediator, participating in both the cyto-protective response and the adaptive cyto-protective response, acting against exogenous and endogenous irritating factors

The core move here is not, trust clinicians who say these work. The core move is, we understand the Agencys balancing test, and we have tried to close the exact gaps the Agency identified. Whether FDA agrees is a separate issue

Schipper, H

Common pitfalls with cell viability assays are: Traditional workflows are labor-intensive and difficult to scale Wash steps, sample manipulation and specialized instrumentation limit throughput and add variability Single endpoint measurements can miss the activation window and misrepresent whats actually happening Questions & Solutions Is my compound toxic to cells

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