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Description
Behavioral tolerance to opioids results from many interacting processes including desensitization, resensitization, and cellular and pass-forward allostasis

The effect of NNMT is achieved by its effect on histone methylation

NiemannPick Disease NPC, type C1 (NPC1) is a lysosomal disorder linked to mutations in the NPC1 gene, leading to the abnormal trafficking and accumulation of lipids, primarily cholesterol, in brain cells

Received December 22, 2025

Neumann et al., 2018
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