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Despite the increase in the plasma concentration of curcuminoids from such formulations, most studies have reported that curcumin metabolites (predominantly glucuronides and sulfates) exhibit poor membrane permeability, extensive renal clearance, and negligible bloodbrain barrier penetration [246, 247]

Moreover, the (KLAKLAK)2 peptide guided by CD44v6-binding (CNLNTIDTC and CNEWQLKSC), Her-2-binding (YCDGFYACYMDV), prostate tumor-targeting (SMSIARL), and bladder tumor-targeting (CSNRDARRC) peptides efficiently inhibited tumor growth with minimal effects on normal tissues 55,56,57,58,59

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doi: 10.3390/md13085156

This can be done for various reasons, including to improve the appearance of scars, hyperpigmentation, or other skin blemishes or to even out the skin tone
