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As for the more general TKIs the sequence homology between IGF-1R and IR-A/B kinase domains presented a major problem and therefore side effects were of great concern ( The IGF-signalling system has long been an area of therapeutic interest in the treatment of breast cancer which was further supported by the findings of both the European Prospective Investigation into Cancer and Nutrition (clinicaltrials.gov database

Preventing and Managing Toxicities of High-Dose Methotrexate

Manufacturing Stable Liposomal Glutathione APIs for Nutraceuticals Producing pharmaceutical-grade glutathione for Type 2 Diabetes requires precise control over chemical and physical parameters to ensure the final product delivers real clinical value

Maintaining mammalian cells ex vivo requires a precisely controlled physiological environment, including temperatures of 28 C39 C, a pH of 7.27.4, and particularly a nutrient-rich media that can support cellular homeostasis (Weber et al., 2025

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This leads to an accumulation of DNA damage, abnormal growth, and cancer