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Nano-sized platinum as a mimic of uricase catalyzing the oxidative degradation of uric acid

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In vitro, human renal proximal tubular epithelial cells (HK-2) were exposed to calcium oxalate monohydrate crystals (1.5 mM), or cells were pretreated with PS-NPs (100 nm, 0.1 mg/mL) for 24 h, followed by the addition of 1.5 mM CaOx for co-treatment