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There was no significant change in the body weight of the mice during the monitoring cycle, indicating that there was no significant toxicity at the administered dose (Fig

*Correspondence: Fang Bian, [email protected]

Another limitation is the lack of standardization in herbal products, which can result in inconsistencies in the concentration and potency of bioactive compounds

Finally, the safety and efficacy of microbiota intervention strategies (such as probiotics and selective antibiotic removal) need to be further validated in large-scale clinical trials to ensure their reproducibility and universality in clinical practice (Wang H

Abuse of and addiction to opioids in some individuals may not be accompanied by concurrent tolerance and symptoms of physical dependence

B., Hampden C