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Hercynylcysteine sulfide can also be synthesized from an L-histidine derivative with an N -benzyl-protected imidazole in good yield, followed by a non-enzymatic reaction with pyridoxal phosphate to yield EGT (Khonde and Jardine 2015

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It has been suggested that due to the upregulation of K ir 4.1, T-type voltage-sensitive Ca 2+ channels (T-VSCCs) in neurons are activated and initiate NMDAR-dependent neuronal bursts, causing the LHb to trigger depression (Zhao et al., 2022)

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We also confirmed these results in a parallel experiment by determining a 2.6 cryo-EM reconstruction of PV3-SC8 bound to GSH and an alternative VP1 hydrophobic pocket binding drug, pleconaril (Supplementary Figs

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